Multiple injections of sotradecol are injected into the abnormal surface veins of the involved leg. The patient's leg is then compressed with either stockings or bandages that they wear usually for 2 weeks after treatment. Patients are also encouraged to walk regularly during that time.

Treatment differs from patient to patient, depending on the extent of the varicosities (size and number). An average of three to four treatments separated by several weeks is required in most cases to achieve a 70%-80% clearing; 100% is not a realistic goal. The treatment sessions last approximately 15 minutes and are done at four to six week intervals to achieve optimal results.

The majority of people who have sclerotherapy performed have satisfying results and little discomfort.

After completion of the initial series of recommended treatments, successfully treated veins are either gone or are much less noticeable. However, patients with a history of spider veins tend to develop new ones (with or without treatment) and a yearly touch up may become necessary. If you have leaking valves in your deep veins, you will likely continue to develop spider veins if the underlying cause is not treated.

Sclerotherapy is a treatment for spider veins, not a cure.